Top 10 Most Influential South African Start-Ups 2021!

Top 10 Most Influential South African Start-Ups 2021! The definition of influential is someone or something that has an impact on or shapes how people act or how things occur. A person who convinces others to listen and do what he suggests is an example of an influential person. These companies have had significant impact in people’s lives throughout South Africa as they have become very successful in their business ventures to reach heights where they inspire many South Africans, especially the youth. Below are the top 10 most influential start-ups in South Africa 2021.


Aerobotics is a data analytics company, using aerial imagery and machine learning algorithms to help farmers identify pest and disease early. Aerobotics is a data analytics company using aerial imagery and machine learning algorithms to develop autonomous unmanned aerial vehicles. The Company offers drone and DJI flight planner app; data processing solutions, and analysis software for agriculture, surveying, gaming, and security industries. Aerobotics provides farmers with an opportunity to make more informed decisions, allowing for a more integrated approach to crop protection and farm management.


AzarGen is a biotech company focused on developing human therapeutic proteins using advanced genetic engineering & synthetic biology. Its focus is to use plants as bioreactors to develop a pipeline of novel and patentable compounds with special emphasis on complex therapeutic proteins. The company’s lead therapeutic candidates are: a biosimilar version of an anti-cancer monoclonal antibody and a recombinant human surfactant protein targeted for various respiratory disease conditions. AzarGen has developed proprietary synthetic DNA promoters for various expression platform applications in plant-made pharmaceuticals, synthetic biology and GM-crop improvement. The AzarGen management team is supported by an experienced advisory board for strategic guidance and intellectual property management.

Alphawave Group

Alphawave Group is a South African start-up that provides actionable intelligence in an always connected world. Alphawave is a specialised technology investment group supporting businesses seeking to do things that are complex to replicate. As organisations require more information about the world, their products and their customers, its group provides actionable intelligence in an always connected world. The portfolio is focused on the Internet of Everything (IoE), consisting of 12 companies, with exceptional domain expertise in interconnected sensor technology, artificial intelligence, electromagnetic fields and virtual reality.


cARscan is team of world class Artificial intelligence experts eager to solve real world business problem through the best utilisation of data and machine learning. Team has proven themselves in building disruptive and innovative AI products for banking, insurance and automotive that were adopted by millions of customers, for which team garnered the Best Data Science team award from Gartner in 2016 and many other Global data and innovation awards.

MaXhosa by Laduma

MAXHOSA AFRICA is a South African knitwear brand founded in 2012 by Laduma Ngxokolo. This was with desire to explore knitwear design solutions that would be suitable for amakrwala (Xhosa initiates). His initial vision was to create a modern Xhosa-inspired knitwear collection that would be suitable for this market. MAXHOSA designs showcase the beauty, culture, language and aspiration of the Xhosa people. Evolved and amended in a modern way and a current design context it translates into a form that resonates with multiple fashion markets globally. Brand Aspiration, become a leading African luxury, premium and mass heritage fashion & lifestyle brand.


RecoMed is South Africa’s largest and fastest growing online healthcare booking platform. Their user friendly platform allows patients to quickly find and make appointments with quality healthcare providers 24/7, without any phone calls or paperwork. It gives healthcare professionals a proven way to grow their practices while improving the patient experience. The company was founded in 2013 by Sheraan Amod, who also serves as the CEO.

Namola App

Namola is South Africa’s leading personal safety app that allows South Africans to keep themselves and their loved ones safe and connected and gets the best emergency assistance straight to the user’s location when needed. It has made the safety of people its core focus. Once the Namola app has been downloaded for free on a mobile phone, a number of safety features become available to keep someone and their loved ones safe.

My Growth Fund Venture Partners

My Growth Fund Venture Partners is a Series A investment firm. With its overall goal to enhance and contribute to economic upliftment of Africa, it provides the tools innovators need to shatter the status quo. Its accelerator, incubators, masterclasses & investments make it the only wall-to-wall enterprise and supplier development company in South Africa. Since 2014 it has obsessively honed what it is good at and that is providing the expert skills, business support and access to capital that entrepreneurs and businesses need to sustainably grow.

Luminary jewellery

Luminary jewellery aims to target the youth market with its designs that are trendy and are much linked to the modern youth culture. Artists such as Flvme, Lucasraps and J Molley have posted themselves on social media wearing Luminary jewellery. Using this marketing strategy of getting celebrities that relate to the youth to promote its products, the company seeks to capture the youth’s attention. This will boost the business’ sales as social medial marketing is arguably the most effective marketing when targeting the youth. is a South African ecommerce retailer and one most innovative ecommerce retailers on the African continent. Its mission is to be the most customer-centric online shopping destination in Africa, built around the simple concept that the customer comes first. All of its focus is dedicated to improving the customer experience, from the moment they arrive on its website to the moment their order arrives at their door. By aligning itself to this philosophy, the company believes will be the #1 shopping destination across Africa.

By Thomas Chiothamisi

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